The palace was owned by the Lambertini, a noble family from Bologna from which Pope Benedict XIV, Prospero Lambertini, emerged. In its halls resounded the words of Cesare Lambertini, a renowned 15th century jurist from Trani. After passing to the Cerdani family in 1608 and then to the Poor Clares, the Campitelli family took ownership in 1746, shaping the building into its current form. An outstanding figure among the Campitellis was Giuseppe, a marshal in the service of Maria Theresa of Austria in the 18th century. The union between Geronima Lepore Campitelli and Baron Ottavio d'Amely gave rise to the D'Amely-Broquier and D'Amely-d'Assisti family branches in the heart of the palace. In its salons, the work of Neapolitan artist Filippo Pascale, dating from the second half of the 18th century, testifies to the artistic wealth of the place.