The structure originally called the Scola Grande synagogue, which in the late 13th century became the church of San Quirico and Giovita and later St. Anne, now houses the Jewish section of the Diocesan Museum of Trani. The building, with a centuries rich history of religious devotion, is characterised by its stone walls, an octagonal drum and a dome, elements reminiscent of Middle Eastern architecture. Of note on the façade is the reuse of a tympanum, thought to be part of the Aron ha-qodesh, the sacred container of the Sefer Torah. Inside, an epigraph dated 1246-1247 reveals the temple's original dedication. The crypt, with the remains of frescoes, preserves tombstones from the destroyed Jewish cemetery. The museum bears witness to the deep connection between Trani and the Jewish Community.